326 Clinical trial publication trends and disease focus: 2015-2019
نویسندگان
چکیده
Dermatology is a broad specialty, and clinical trial resources are limited. We sought to describe current disease focus resource allocation. tabulated trials from 5 dermatology journals (JAMA Dermatology, BJD, JID, JAAD, JEADV) 2015-2019. Study characteristics, funding, were extracted. Results descriptive, associations with industry funding investigated logistic regression. 265 met inclusion criteria. Trials targeted inflammatory (n=156, 58.9%), neoplastic (n=60, 22.6%), surgical techniques/outcomes (n=19, 7.17%), cosmetic infectious (n=11, 4.15%) conditions. Fifty-eight specific conditions identified. The most common psoriasis (n=75, 28.3%), actinic keratoses (n=30, 11.3%), atopic dermatitis (n=23, 8.68%), techniques (n=13, 4.91%). Other diseases constituted <5% of trials. Most randomized (n=245, 93.5%) controlled (n=243, 92.4%). Active controls prevalent (n=104, 39.5%), but less in (n=18, 24.7%) (n=4, 18.2%). industry-funded 58.87%). was for (OR 10.2, 95% CI: 3.20-32.4, reference = studies). focused on small number diseases. processes such as pruritus, wounds, hidradenitis suppurativa, carry significant morbidity have relatively minimal representation hope these data offer perspective help identify under-represented needs.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2021
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2021.02.348